Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p393 | Osteoporosis: treatment | ECTS2016

Long-term high-dose resveratrol supplementation reduces bone mass and strength in rats

Juul Ornstrup Marie , Bruel Annemarie , Skovhus Thomsen Jesper , Harslof Torben , Lomholt Langdahl Bente , Bonlokke Pedersen Steen

Background: Resveratrol (RSV), a natural polyphenolic compound, stimulates osteoblasts and inhibits osteoclast activation in vitro. Conflicting results have emerged from short-term studies in rodents but a recent study in men suggests a positive effect on BMD.Aim: To evaluate effects of short- and long-term high-dose RSV supplementation on bone in immobilized and non-immobilized rats.Methods: A total of 72 female Wistar ra...